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Updated: Jul 29, 2025

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces
Published on: January 7, 2020
Macrophage Nrf 2 the rescue
Jennifer L Stow1, Matthew J Sweet1
1Institute for Molecular Bioscience (IMB), IMB Centre for Cell Biology of Chronic Disease and Australian Infectious Diseases Research Centre, The University of Queensland , Brisbane, Queensland, Australia.
Abstract:
The exuberant phagocytosis of apoptotic cell corpses by macrophages in Drosophila embryos creates highly oxidative environments. Stow and Sweet discuss work from Clemente and Weavers (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202203062) showing for the first time how macrophage Nrf2 is primed to help sustain immune function and mitigate bystander oxidative damage.
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