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Related Concept Videos

Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Related Experiment Video

Updated: Jul 29, 2025

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
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Speaking the Same Language: Team Science Approaches in Aging Research for Integrating Basic and Translational Science

Stacey J Sukoff Rizzo1,2, Toren Finkel1,2, Susan L Greenspan2

  • 1Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Innovation in Aging
|May 22, 2023
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Summary

Basic aging research is translating into new health span and longevity interventions. Promoting collaboration through team science accelerates the development of novel therapies and clinical trials for aging.

Keywords:
Animal modelsGeroscienceTherapeutic interventionsTranslation

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Area of Science:

  • Geroscience
  • Translational Medicine
  • Biomedical Research

Background:

  • Aging research has accumulated significant insights over two decades.
  • Basic science discoveries are increasingly impacting medical practice.
  • Translating geroscience requires integrating basic, translational, and clinical research.

Purpose of the Study:

  • To accelerate the translation of aging research into health span and longevity interventions.
  • To foster collaboration and a common language among diverse aging research disciplines.
  • To facilitate the development and testing of novel therapeutic agents for aging.

Main Methods:

  • Identifying new biomarkers and molecular targets for therapeutic intervention.
  • Conducting translational in vivo studies to assess intervention efficacy.
  • Promoting multidisciplinary collaboration across fields like molecular biology, neuroscience, and pharmacology.

Main Results:

  • Efforts are underway to reduce barriers to collaborative interactions in aging research.
  • A common language is being promoted through team science initiatives.
  • The ultimate goal is to accelerate first-in-human clinical trials for aging interventions.

Conclusions:

  • Integrating basic, translational, and clinical research is essential for advancing geroscience.
  • Multidisciplinary collaboration is key to developing novel interventions for aging.
  • Team science approaches are crucial for accelerating the discovery and application of longevity and health span therapies.