Naringenin ameliorates Cyclophosphamide-induced nephrotoxicity in experimental model

Area of Science:

• Pharmacology
• Toxicology
• Nephrology

Background:

• Cyclophosphamide (CP) is a widely used chemotherapeutic agent.
• Renal damage is a significant toxic effect associated with CP treatment.
• Naringenin (NG) is a flavonoid with known antioxidant properties.

Purpose of the Study:

• To evaluate the protective effects of Naringenin (NG) against cyclophosphamide (CP)-induced nephrotoxicity in a rat model.
• To investigate the underlying mechanisms of NG's renoprotective action.

Main Methods:

• A rat model was established using intraperitoneal injection of CP.
• Rats were co-administered orally with two different doses of NG (100 mg/kg and 200 mg/kg) alongside CP.
• Renal function markers (creatinine, urea), oxidative stress indicators (antioxidant activity, lipid peroxidation), and histopathological changes were assessed.

Main Results:

• Coadministration of NG with CP significantly improved renal function markers compared to the CP-only group.
• NG treatment enhanced antioxidant capacities and reduced lipid peroxidation in renal tissues.
• Histopathological and immunohistochemical analyses confirmed the renoprotective effects of NG against CP-induced damage.

Conclusions:

• Naringenin (NG) demonstrates significant potential in mitigating cyclophosphamide (CP)-induced nephrotoxicity.
• NG's protective mechanism involves the restoration of antioxidant defense systems and reduction of oxidative stress.
• These findings support further research into NG and its analogs for clinical application in preventing CP-related kidney damage.