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Complications in post-mortem GHB cut-off values in urine samples: A case report
N H C Loos1,2, K E van den Hondel3, U J L Reijnders3
1The Netherlands Cancer Institute, Division of Pharmacology, Amsterdam, the Netherlands.
Gamma-hydroxybutyric acid (GHB) is a drug of abuse. Post-mortem GHB formation complicates interpretation, but urine analysis with a 30 mg/L cut-off aids in determining exogenous exposure.
Area of Science:
- Forensic Toxicology
- Pharmacology
Background:
- Gamma-hydroxybutyric acid (GHB) is a substance of abuse affecting the GABAergic system, leading to euphoria and altered mood.
- Fatal mixed intoxications involving GHB present challenges in post-mortem interpretation due to potential post-mortem formation of GHB.
- GHB levels can be influenced by post-mortem interval and sample storage conditions.
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