[Analysis of HLA-CW 3 antigens]

HLA-CW3 antigen was serologically analyzed by using antisera including defined at 9th International Histocompatibility Workshop (9th IHW) and panel cells from Japanese. On microcytotoxicity tests, the reaction patterns of these antisera against CW3 positive panel cells are divided into three groups. It was thought that the those three different patterns of the reaction could be the reflection of three new antigens, CW3.1, CW3.2, and CW3.3. This thought was verified by population as well as family studies. In population study using random and family panels, CW3.1 showed strong linkage disequilibrium with B35 and BW62, whereas CW3. 2 with BW60, BW61, and B13. In family study, CW3.1 and CW3.2 were inherited independently in two families. CW3.3 appeared to be identical with CX46 defined at 8th Japan Histocompatibility Workshop.