Related Experiment Video
Updated: Jul 29, 2025
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
20.0K
Hypertensive Emergency As Initial Presentation of Systemic Sclerosis Sine Scleroderma
Sumugdha Rayamajhi1, Shailendra Sharma2, Subash Regmi3
1Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA.
Cureus
|May 22, 2023
Summary
Scleroderma renal crisis (SRC) is a rare cause of hypertensive emergency. This case highlights SRC
Area of Science:
- Nephrology
- Rheumatology
- Critical Care Medicine
Background:
- Hypertensive emergency is a frequent reason for emergency room visits.
- Scleroderma renal crisis (SRC) is a rare but severe cause of hypertensive emergency.
- SRC presents with acute, severe hypertension and rapid decline in kidney function.
Observation:
- A patient presented with hypertensive emergency and renal failure.
- The patient tested positive for anti-Scl 70 and RNA polymerase III antibodies.
- These antibodies are characteristic markers for Scleroderma renal crisis.
Findings:
- Despite supportive care and ACE inhibitor treatment, the patient's condition worsened.
- The patient progressed to end-stage kidney disease.
Implications:
- Early recognition of SRC is crucial for prompt management.
- This case underscores the aggressive nature of SRC, even with treatment.
- Further research into novel therapeutic strategies for SRC is warranted.
Related Concept Videos
01:28Hypertension I: Introduction
27
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
27
01:29Hypertension II: Pathophysiology
23
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
23
01:18Disorders of the Autonomic Nervous System
726
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
726
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
35
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
35
01:24Blood Pressure Imbalances and Circulatory Shock
823
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
823
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
472
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
472