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Antifungal properties of (2S, 4R)-Ketoconazole sulfonamide analogs

Benjamin E Blass1, Sumant Puri2, Rishabh Sharma2

  • 1Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, United States.

Frontiers in Drug Discovery
|May 22, 2023
PubMed

Insights

Researchers investigated novel sulfonamide analogs of ketoconazole for antifungal properties. These compounds show potential for treating invasive candidiasis caused by drug-resistant Candida species.

Area of Science:

  • Medical Mycology
  • Medicinal Chemistry

Background:

  • Invasive candidiasis presents a high mortality risk, particularly in immunocompromised individuals.
  • Candida albicans and Candida glabrata are leading causes of invasive candidiasis.
  • Increasing antifungal drug resistance necessitates the development of novel therapeutic agents.

Purpose of the Study:

  • To evaluate the in vitro antifungal activity of novel sulfonamide analogs of (2S, 4R)-Ketoconazole.
  • To identify potential new treatments against key Candida pathogens.

Main Methods:

  • Synthesis and in vitro testing of a series of sulfonamide analogs.
  • Antifungal susceptibility testing against Candida albicans and Candida glabrata.

Main Results:

  • The study reports on the in vitro antifungal activity of the synthesized compounds.
  • Specific activity data against C. albicans and C. glabrata are presented.

Conclusions:

  • The novel sulfonamide analogs demonstrate in vitro antifungal potential.
  • These compounds represent a promising starting point for developing new agents against invasive candidiasis.
Keywords:
Candida albicansCandida glabrataantifungal agentantimicrobial agentsketoconazole

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