The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Feasibility Phase

Area of Science:

• Nutrition Science
• Hematology
• Inflammation Research

Background:

• Chronic inflammation is central to Myeloproliferative Neoplasm (MPN) pathogenesis.
• JAK inhibitors manage cytokine levels but have side effects.
• Nutritional interventions offer a low-risk strategy to reduce inflammation and symptoms in MPN.

Approach:

• A randomized, parallel-arm study assessed the feasibility of a Mediterranean diet intervention in MPN patients.
• Participants were assigned to either a Mediterranean diet or standard US Dietary Guidelines (USDA).
• Education, dietician counseling, and dietary resources were provided equally; feasibility, adherence, and symptom burden were monitored over 15 weeks.

Key Points:

• The Mediterranean diet demonstrated comparable feasibility to the standard USDA diet for MPN patients.
• Over 80% of the Mediterranean diet group achieved high adherence (≥8 score), versus <50% in the USDA group.
• Symptom burden improved in both groups, with no significant changes in inflammatory cytokines or gut microbiome composition.

Conclusions:

• MPN patients can adhere to a Mediterranean eating pattern with adequate support and education.
• Dietary interventions show promise as a complementary component in MPN care.
• This approach may be applicable to managing other chronic clonal hematologic conditions.