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Related Experiment Video

Updated: Jul 29, 2025

A Method for 3D Reconstruction and Virtual Reality Analysis of Glial and Neuronal Cells

A Method for 3D Reconstruction and Virtual Reality Analysis of Glial and Neuronal Cells

Published on: September 28, 2019

General, Open-Source Vertex Modeling in Biological Applications Using Tissue Forge.

T J Sego¹, Tien Comlekoglu^2,3, Shayn M Peirce²

¹Department of Medicine, University of Florida, Gainesville, FL, USA.

Research Square

|May 22, 2023

Summary

This summary is machine-generated.

We developed an open-source vertex model methodology in Tissue Forge, enhancing accessibility and reproducibility for studying multicellular systems like epithelial tissues. This approach integrates vertex and particle-based modeling for diverse biophysical simulations.

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Last Updated: Jul 29, 2025

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Area of Science:

Biophysics
Computational Biology
Developmental Biology

Background:

Vertex models are crucial for simulating multicellular systems, particularly epithelial tissues, but often lack accessibility and reproducibility due to closed-source implementations.
Existing vertex models can be difficult for researchers without extensive software development or numerical methods expertise to utilize.
There is a need for open-source, extensible vertex modeling tools that facilitate collaboration and diverse research applications.

Conclusions:

The developed vertex model methodology in Tissue Forge significantly improves accessibility and reproducibility for studying multicellular systems.
This open-source approach fosters collaboration and allows for the development of complex, mixed-method models.
The methodology is applicable across various scientific disciplines, encouraging broader adoption and community contributions.