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Validation Study on Risk-Reduction Activities after Exposure to a Personalized Breast Cancer Risk-Assessment
Tianyi Wang1,2, Mandy Che1,3, Yash S Huilgol4
1UC San Francisco Department of Surgery, San Francisco, USA.
Research Square
|May 22, 2023
Summary
The Breast Health Decisions tool improved uptake of lifestyle changes for breast cancer risk reduction. However, healthcare provider barriers may limit the use of endocrine medications for high-risk women.
Area of Science:
- Oncology
- Preventive Medicine
- Health Communication
Background:
- Breast cancer risk assessment is crucial for guiding preventive strategies.
- The Women Informed to Screen Depending on Measures of risk (WISDOM) trial investigated personalized screening.
- Effective risk communication tools are needed for high-risk individuals.
Approach:
- A validation study assessed the Breast Health Decisions (BHD) tool in 318 high-risk women from the WISDOM trial.
- The BHD tool uses patient-friendly visuals and simple language to explain risk and prevention.
- Participants were assessed before and three months after using the BHD tool.
Key Points:
- Prior to BHD use, 4.7% used endocrine risk reduction, 38.7% reduced alcohol, and 62.6% increased exercise.
- After BHD, uptake increased: 8.4% considered endocrine risk reduction, 33% considered alcohol reduction, and 46% considered exercise.
- While lifestyle intervention uptake improved, endocrine risk reduction medication use showed less significant change.
Conclusions:
- The BHD tool effectively promotes patient engagement with lifestyle modifications for breast cancer risk reduction.
- Healthcare provider-level barriers may hinder the optimal use of endocrine risk reduction medications in high-risk populations.
- Further research is needed to address systemic barriers to prescribing preventive endocrine therapy.
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