Related Experiment Video

Updated: Jul 29, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

12.6K

Acute Colonic Perforation with Septic Shock Secondary to Disseminated Histoplasmosis in an Autologous Bone Marrow

Harsimrandeep Bhatti1, Enkhbileg Batbileg1, Srijisnu De1

  • 1Department of Internal Medicine, Las Palmas Del Sol Medical Center, El Paso, TX, USA.

Infection and Drug Resistance
|May 22, 2023
PubMed

Insights

Disseminated histoplasmosis is a rare complication in hematopoietic cell transplant recipients. This case highlights acute caecal perforation as a severe manifestation in an immunocompromised patient.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Hematopoietic Stem Cell Transplantation

Background:

  • Histoplasma capsulatum is an opportunistic fungal pathogen.
  • Immunocompromised individuals are susceptible to disseminated infections.
  • Post-transplant histoplasmosis is rare, affecting less than 1% of hematopoietic cell transplant recipients.

Observation:

  • A 71-year-old patient presented with progressive weakness and shortness of breath.
  • The patient had previously undergone autologous bone marrow transplant for plasma cell dyscrasia.
  • The patient developed acute caecal perforation.

Findings:

  • Disseminated histoplasmosis was diagnosed as the cause of caecal perforation.
  • This represents an exceedingly rare presentation of post-transplant histoplasmosis.

Implications:

  • This case underscores the importance of considering disseminated histoplasmosis in immunocompromised patients with unusual presentations.
  • Early diagnosis and treatment are crucial for managing severe complications like gastrointestinal perforation.
  • Further research into risk factors and management strategies for post-transplant histoplasmosis is warranted.
Keywords:
bone marrow transplantcolonic perforationdisseminated histoplasmosisinfectious diseasepancytopeniasurgery

More Related Videos

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation14:43

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation

Published on: October 1, 2012

18.4K
Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice10:02

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

2.1K

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
428
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
364
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
135
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
228