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Updated: Jul 29, 2025
07:58
Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
Published on: May 30, 2017
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Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development
David A Montero1, Roberto M Vidal2,3, Juliana Velasco4,5
1Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Frontiers in Medicine
|May 22, 2023
Summary
Vibrio cholerae causes cholera and evolves rapidly, posing a global health challenge. Understanding its virulence, immune response, and vaccine development is crucial for control.
Area of Science:
- Microbiology and immunology
- Infectious disease epidemiology
Background:
- Vibrio cholerae is the bacterium responsible for cholera, a severe diarrheal illness with significant global health implications.
- Cholera outbreaks are exacerbated by poor sanitation and limited access to safe water, particularly in disaster-affected areas.
Purpose of the Study:
- To review the evolution of Vibrio cholerae virulence and pathogenesis.
- To summarize the immune responses elicited by V. cholerae infection.
- To provide an overview of current and emerging cholera vaccine technologies.
Main Methods:
- Narrative review of existing scientific literature.
- Analysis of virulence factors and host-pathogen interactions.
- Evaluation of cholera vaccine research and development.
Main Results:
- Vibrio cholerae exhibits remarkable adaptability and evolution, increasing outbreak risks.
- The pathogen possesses multiple virulence factors crucial for intestinal colonization and disease causation.
- V. cholerae infection induces an inflammatory response that shapes immune memory.
Conclusions:
- Effective control of cholera is challenged by V. cholerae's evolutionary capacity.
- Further research is needed to address knowledge gaps in V. cholerae pathogenesis and immunity.
- Development of next-generation cholera vaccines is essential for improved disease prevention.
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