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A Rate-Dependent Cell Microinjection Model Based on Membrane Theory.

Shengzheng Kang1, Zhicheng Song2, Xiaolong Yang3

  • 1School of Automation, Nanjing University of Information Science and Technology, Nanjing 210044, China.

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|May 22, 2023
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A new mechanical model improves cell microinjection by accounting for injection speed. This rate-dependent model enhances efficiency and success rates in biomedical applications.

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Area of Science:

  • Biomedical Engineering
  • Cellular Mechanics

Background:

  • Microinjection is vital for delivering materials into cells.
  • Limited understanding of cell mechanics hinders microinjection efficiency.

Purpose of the Study:

  • To develop a novel rate-dependent mechanical model for cell microinjection.
  • To improve the prediction of cell deformation and injection force based on speed.

Main Methods:

  • Proposed a new rate-dependent mechanical model based on membrane theory.
  • Incorporated injection velocity and acceleration into the elastic coefficient.
  • Validated the model using numerical simulations and experimental data.

Main Results:

  • The model accurately predicts cell mechanical responses at speeds up to 2 mm/s.
  • Demonstrated the influence of injection speed on cell deformation and stress distribution.
  • Established an analytical equilibrium equation for injection force and cell deformation.

Conclusions:

  • The proposed model offers a more generalized and practical approach to cell microinjection.
  • This model has potential for enhancing automatic batch cell microinjection efficiency.
  • Improved understanding of cell mechanics is crucial for optimizing microinjection protocols.