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Published on: January 12, 2018
[Epidemiological characterization of COVID-2019 in Mexican pregnant women: a cohort study]
María Guadalupe Berumen-Lechuga1, Carlos José Molina-Pérez2, Luis Rey García-Cortés3
1Instituto Mexicano del Seguro Social, Órgano de Operación Administrativa Desconcentrada Estado de México Poniente, Coordinación Auxiliar Médica de Investigación en Salud. Toluca, Estado de México, México.
Insights
COVID-19 infection during pregnancy poses risks such as preterm birth and maternal death. However, COVID-19 vaccination in pregnant individuals was found to be safe, with no adverse events reported for mothers or newborns.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Epidemiology
Context:
- Pregnancy involves significant cardiorespiratory and immunological adaptations, increasing vulnerability to infections like COVID-19.
- Understanding COVID-19's impact on pregnant populations is crucial for maternal and fetal health outcomes.
- Mexican pregnant women represent a key demographic for studying disease-specific risks and management strategies.
Purpose:
- To epidemiologically characterize COVID-19 cases in pregnant women within Mexico.
- To assess the safety and efficacy of COVID-19 vaccination in this high-risk group.
- To identify key complications and outcomes associated with COVID-19 during pregnancy.
Summary:
- A cohort study analyzed 758 pregnant Mexican women with COVID-19.
- Key findings include high rates of cesarean delivery (85%), prematurity (53.5%), and preeclampsia (26.2%).
- Vaccination data indicated no serious adverse events, with BioNTech Pfizer being the most common vaccine.
Impact:
- COVID-19 in pregnancy is linked to increased risks of preterm birth, preeclampsia, and maternal mortality.
- The study supports the safety of COVID-19 vaccination for pregnant women and their newborns.
- Findings inform public health policies and clinical guidance for managing COVID-19 in pregnant populations.
Background:
COVID-19 in pregnancy can increase the risk of complications due to the cardiorespiratory and immunological changes typical of pregnancy.
Objective:
To report the epidemiological characterization of COVID-19 in Mexican pregnant women.
Material And Methods:
Cohort study on pregnant women with a positive COVID-19 test, which were followed until delivery and one month later.
Results:
758 pregnant women were included in the analysis. Mothers' mean age was 28.8 ± 6.1 years; the majority were workers 497 (65.6%) and with an urban origin (482, 63.6%); the most common blood group was O with 458 (63.0%); 478 (63.0%) were nulliparous women and more than 25% had some comorbidities; the average gestation weeks at infection were 34.4 ± 5.1 weeks; only 170 pregnant women (22.4%) received vaccination; the most frequent vaccine was BioNTech Pfizer (96, 60%); there were no serious adverse events attributed to vaccination. The mean gestational age at delivery was 35.4 ± 5.2 weeks; 85% of pregnancies were cesarean section; the most frequent complication was prematurity (406, 53.5%), followed by preeclampsia (199, 26.2%); there were 5 cases of maternal death and 39 cases of perinatal death.
Conclusions:
COVID-19 in pregnancy increases the risk of preterm birth, preeclampsia, and maternal death. Vaccination against COVID-19 in this series showed no risk for pregnant women and their newborns.
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