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The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis

Athena Jessica S Ong1,2, Cerys E Bladen1,2, Tara A Tigani1,2

  • 1Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.

Proceedings of the National Academy of Sciences of the United States of America
|May 22, 2023
PubMed
Summary

Keap1 deficiency causes lethal embryonic defects by activating NRF2, leading to abnormal lysosome production. This highlights the critical role of the KEAP1-NRF2 pathway in maintaining lysosomal homeostasis for development.

Keywords:
KEAP1NRF2TFEB/TFE3lysosomezebrafish

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