Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of non-culprit coronary artery lesions assessed by intravascular ultrasound in patients with ST-segment elevation myocardical infarction.

La Clinica terapeutica·2026
Same author

A living biobank of sarcoma patient-derived cell cultures reveals multi-omic and functional insights that capture disease heterogeneity.

Clinical and translational medicine·2026
Same author

Modeling cancer with bacteria-integrated tumor microenvironments using biomaterials: Emerging concepts and opportunities.

Materials today. Bio·2026
Same author

Injectable Silk Fibroin-Puerarin Hydrogels with Tunable Supramolecular Organization as a Potential Platform for Tissue Engineering.

ACS omega·2026
Same author

Advances in light-based 3D bioprinting.

Biofabrication·2026
Same author

Extracellular vesicles: Whisperers of tumor immune evasion.

Cancer cell·2026

Related Experiment Video

Updated: Jul 29, 2025

Engineered Vascularized Muscle Flap
08:18

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

8.3K

Vascularized adipose tissue engineering: moving towards soft tissue reconstruction.

Arne Peirsman1,2,3,4, Huu Tuan Nguyen3, Michiel Van Waeyenberge1

  • 1Plastic, Reconstructive and Aesthetic Surgery, University Hospital Ghent, Ghent, Belgium.

Biofabrication
|May 22, 2023
PubMed
Summary

Vascularized adipose tissue engineering (VATE) offers promising solutions for soft tissue defects, overcoming limitations of current reconstructive methods. This review explores VATE strategies, cell sources, and future clinical applications.

Keywords:
adipose tissueadipose-derived stem cellbiomaterialsendothelial cellregenerative medicinesoft tissue reconstructiontissue engineering

More Related Videos

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

8.9K
Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering
07:09

Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

Published on: April 30, 2017

12.5K

Related Experiment Videos

Last Updated: Jul 29, 2025

Engineered Vascularized Muscle Flap
08:18

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

8.3K
Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

8.9K
Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering
07:09

Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

Published on: April 30, 2017

12.5K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Soft tissue defects pose significant clinical challenges, often resulting from trauma, congenital issues, or cancer surgery.
  • Current reconstruction methods like synthetic fillers and autologous fat grafting have notable drawbacks.
  • Vascularized adipose tissue engineering (VATE) presents a potential solution to these limitations.

Purpose of the Study:

  • To review the fundamental characteristics of functional adipose tissue.
  • To explore various cell sources and their application in advanced VATE techniques.
  • To highlight the potential of extracellular vesicles in VATE and discuss future clinical prospects.

Main Methods:

  • Summarized adipose tissue structure, function, cell types, development, and extracellular matrix (ECM).
  • Discussed cell sources and their integration into VATE strategies.
  • Overviewed techniques including biomaterial scaffolds, hydrogels, ECMs, spheroids, organoids, cell sheets, 3D printing, and microfluidics.

Main Results:

  • Detailed the essential components of functional adipose tissue.
  • Presented a comprehensive overview of current VATE methodologies and cell sources.
  • Emphasized the emerging role of extracellular vesicles in enhancing VATE efficacy.

Conclusions:

  • VATE strategies show significant potential for addressing soft tissue reconstruction challenges.
  • Further research into VATE techniques and extracellular vesicles is crucial for clinical translation.
  • This review provides a roadmap for advancing VATE towards successful clinical applications.