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Updated: Jul 29, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
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A prospective study on varicose veins surgery impact on systemic endothelial function evaluated by arterial brachial

Leandro Nóbrega1,2, Rita Cardoso3,4, Adelino Leite-Moreira3

  • 1Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal.

Vascular
|May 22, 2023
PubMed

Insights

Varicose vein surgery did not significantly alter endothelial function, as measured by flow-mediated dilation (FMD). This study suggests surgery may not improve endothelial dysfunction in chronic venous disease patients.

Area of Science:

  • Vascular Surgery
  • Cardiovascular Physiology
  • Endothelial Function Assessment

Background:

  • Chronic venous disease (CVD) is common, with endothelial dysfunction central to its pathology.
  • Flow-mediated dilation (FMD) is a key test for assessing endothelial function.

Purpose of the Study:

  • To investigate the impact of varicose vein (VV) surgery on FMD.
  • To determine if VV surgery influences endothelial function in patients with superficial CVD.

Main Methods:

  • Prospective study of 42 patients with superficial CVD and saphenous incompetence.
  • FMD measurements taken before and 6 months after VV surgery.
  • Blinded post-operative evaluation to ensure objectivity.

Main Results:

  • Median pre-operative FMD was 4.20% (±1.30).
  • Median post-operative FMD was 4.56% (±1.25).
  • No statistically significant difference in FMD was observed (p = 0.819).

Conclusions:

  • The study findings do not support the hypothesis that VV surgery improves overall endothelial dysfunction.
  • Further research is required to validate these results and explore potential nuances.
Abstract

Keywords:
Varicose veinsregional blood flowssurgeryultrasonographyvascular endothelium

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