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Role of non-coding RNAs in neuroblastoma
Ali Arash Anoushirvani1, Arezoo Jafarian Yazdi2, Sanaz Amirabadi3
1Department of Internal Medicine, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Cancer Gene Therapy
|May 22, 2023
Summary
Non-coding RNAs (ncRNAs) are crucial in neuroblastoma, a common childhood cancer. This review explores their diverse roles and functions in this neural crest-derived malignancy.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Neuroblastoma is the most common extracranial childhood cancer, originating from neural crest cells.
- Non-coding RNAs (ncRNAs) are implicated in various cancers, regulating gene networks.
- ncRNAs can be deregulated in cancer through genetic or epigenetic alterations, acting as oncogenes or tumor suppressors.
Purpose of the Study:
- To review the diverse roles and functions of non-coding RNAs (ncRNAs) in neuroblastoma.
- To highlight the regulatory mechanisms and potential impact of ncRNAs in neuroblastoma development and progression.
Main Methods:
- Literature review of recent sequencing and profiling studies on ncRNAs in human cancers.
- Analysis of research on ncRNA deregulation in neuroblastoma.
- Examination of ncRNA secretion via exosomes and intercellular transfer.
Main Results:
- ncRNAs are frequently deregulated in human cancers, including neuroblastoma.
- Dysregulated ncRNAs can function as oncogenes or tumor suppressors, contributing to cancer hallmarks.
- ncRNAs secreted in exosomes can influence recipient cell function, a process requiring further investigation in neuroblastoma.
Conclusions:
- ncRNAs play significant roles in the development and progression of neuroblastoma.
- Understanding ncRNA functions and regulatory mechanisms is essential for neuroblastoma research.
- Further studies are needed to fully elucidate the complex roles of ncRNAs in neuroblastoma, including their exosomal transfer.
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