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S100 proteins in cardiovascular diseases

Yue Zhou1, Yiwen Zha1, Yongqi Yang1

  • 1Medical College, Yangzhou University, Yangzhou, China.

Molecular Medicine (Cambridge, Mass.)
|May 22, 2023
PubMed

Insights

S100 proteins play a key role in cardiovascular diseases, impacting their development and progression. Research into these proteins offers new strategies for preventing and treating heart conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • S100 proteins are a family of calcium-binding proteins with diverse cellular functions.
  • Aberrant S100 protein expression is linked to various pathologies, including CVDs.

Purpose of the Study:

  • To review the current research on the involvement of S100 protein family members in cardiovascular diseases.
  • To elucidate the biological mechanisms underlying the role of S100 proteins in cardiac function and dysfunction.

Main Methods:

  • Literature review of studies investigating S100 proteins and cardiovascular diseases.
  • Analysis of research on the expression patterns and functional roles of specific S100 proteins in the cardiovascular system.

Main Results:

  • S100 proteins are differentially expressed in various cardiovascular conditions.
  • Specific S100 proteins are implicated in key processes such as inflammation, cell proliferation, and extracellular matrix remodeling in the heart.
  • Evidence suggests S100 proteins can act as both protective and detrimental factors in cardiovascular disease.

Conclusions:

  • S100 proteins represent a significant area of research for understanding cardiovascular disease.
  • Further investigation into S100 protein functions may reveal novel therapeutic targets for CVD prevention and treatment.
  • Understanding S100 protein mechanisms could improve diagnostic and prognostic strategies for cardiovascular conditions.

Keywords:
Cardiovascular diseasesRAGES100 proteinsTLR-4

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