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A High-Throughput Platform for Culture and 3D Imaging of Organoids
Published on: October 14, 2022
Development trends of human organoid-based COVID-19 research based on bibliometric analysis
Minghui Li1,2, Yuhan Yuan1, Ting Zou2
1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China.
Abstract:
Coronavirus disease 2019 (COVID-19), a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a catastrophic threat to human health worldwide. Human stem cell-derived organoids serve as a promising platform for exploring SARS-CoV-2 infection. Several review articles have summarized the application of human organoids in COVID-19, but the research status and development trend of this field have seldom been systematically and comprehensively studied. In this review, we use bibliometric analysis method to identify the characteristics of organoid-based COVID-19 research. First, an annual trend of publications and citations, the most contributing countries or regions and organizations, co-citation analysis of references and sources and research hotspots are determined. Next, systematical summaries of organoid applications in investigating the pathology of SARS-CoV-2 infection, vaccine development and drug discovery, are provided. Lastly, the current challenges and future considerations of this field are discussed. The present study will provide an objective angle to identify the current trend and give novel insights for directing the future development of human organoid applications in SARS-CoV-2 infection.
Insights
This bibliometric analysis reviews human organoid research for Coronavirus disease 2019 (COVID-19). It maps publication trends, key contributors, and research hotspots, offering insights into COVID-19 organoid applications.
Area of Science:
- Biomedical Research
- Infectious Diseases
- Stem Cell Biology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global health crisis.
- Human stem cell-derived organoids offer a valuable model for studying SARS-CoV-2 infection.
- Existing reviews lack a systematic analysis of organoid research trends in COVID-19.
Purpose of the Study:
- To systematically analyze the research status and development trends of organoid applications in COVID-19 research.
- To identify key research hotspots, contributing entities, and publication patterns.
- To provide insights for future directions in organoid-based COVID-19 research.
Main Methods:
- Bibliometric analysis of publications and citations related to organoids and COVID-19.
- Analysis of publication trends, geographical distribution, and institutional contributions.
- Co-citation analysis of references and sources to identify research clusters and hotspots.
Main Results:
- Characterization of annual publication and citation trends.
- Identification of leading countries, regions, and organizations in the field.
- Summary of organoid applications in understanding SARS-CoV-2 pathology, vaccine development, and drug discovery.
- Identification of current challenges and future research directions.
Conclusions:
- Bibliometric analysis provides a comprehensive overview of organoid-based COVID-19 research.
- The study highlights key trends and identifies areas for future investigation.
- Organoids remain a critical tool for advancing COVID-19 research, from basic science to therapeutic development.
