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Updated: Jul 29, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Functionalization of arylacetic acids via directing-group-assisted remote meta-C-H activation
Dasari Srinivas1, Kurella Mounika1, Gedu Satyanarayana1
1Department of Chemistry, Indian Institute of Technology (IIT), Hyderabad, Kandi, Sangareddy - 502284, Telangana, India. gvsatya@chy.iith.ac.in.
Abstract:
Herein, we report the first microwave-assisted remote-C-H functionalization aided by a simple nitrile directing template. Notably, the present protocol showed a broad substrate scope VIA enabling meta-C-H arylation, acetoxylation, and cyanation. Significantly, the microwave-accelerated meta-C-H functionalization was effective with short reaction times without compromising yields and site selectivity. In addition, ibuprofen drug diversification was accomplished by carrying out arylation, acetoxylation, and cyanation. Importantly, meta-dual-hetero functionalization has been presented.
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