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The relationship between epicardial adipose tissue thickness and coronary artery disease progress

Enes Con, Ahmet Yilmaz, Hakan Suygun

    Bratislavske Lekarske Listy
    |May 23, 2023
    PubMed

    Insights

    Epicardial adipose tissue thickness is linked to coronary artery disease progression. Thicker epicardial fat is associated with more severe coronary artery disease and calcific-atherosclerotic changes.

    Area of Science:

    • Cardiology
    • Medical Imaging
    • Biomedical Research

    Background:

    • Epicardial adipose tissue (EAT) is metabolically active and associated with inflammation.
    • Inflammation plays a key role in the progression of coronary artery disease (CAD).

    Purpose of the Study:

    • To investigate the relationship between epicardial adipose tissue thickness and the progression of coronary artery disease.

    Main Methods:

    • Coronary angiography and echocardiographic measurements of EAT thickness were performed on 50 patients.
    • Patients were categorized into two groups based on EAT thickness (<0.55 cm and ≥0.55 cm).

    Main Results:

    • No significant differences in gender, diabetes, age, or hypertension were observed between groups.
    • Epicardial adipose tissue thickness (>0.5 cm), ejection fraction, and smoking were significantly related to coronary progression.
    • Patients without stenotic changes had statistically significantly lower EAT thickness (p < 0.005).

    Conclusions:

    • A significant independent relationship exists between epicardial adipose tissue thickness and coronary artery progression.
    • Increased EAT thickness is implicated in the development of coronary artery stenosis and calcific-atherosclerotic changes.
    • A positive correlation was confirmed between EAT thickness and coronary artery disease severity.
    Abstract

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