Related Experiment Video
Updated: Jul 29, 2025
12:59
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.7K
Decreased Muscle Strength in Children With Repaired Tetralogy of Fallot: Relation With Exercise Capacity.
Graziëlla Eshuis1, Hiske van Duinen2, Otto T H M Lelieveld3
1Department of Pediatric Cardiology University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Center for Congenital Heart Disease Groningen The Netherlands.
Journal of the American Heart Association
|May 23, 2023
Summary
Children with repaired tetralogy of Fallot exhibit decreased muscle strength, impacting their exercise capacity. This study highlights a strong correlation between muscle strength and peak oxygen uptake in these pediatric patients.
Area of Science:
- Pediatric Cardiology
- Exercise Physiology
- Rehabilitation Medicine
Background:
- Tetralogy of Fallot is a congenital heart defect requiring surgical repair.
- Post-surgical outcomes in pediatric patients often include considerations for physical development and exercise capacity.
- Assessing muscle strength is crucial for understanding functional limitations in children with repaired Tetralogy of Fallot.
Purpose of the Study:
- To compare muscle strength in pediatric patients with repaired Tetralogy of Fallot against healthy controls.
- To investigate the correlation between muscle strength and exercise capacity, specifically peak oxygen uptake.
- To identify factors influencing exercise performance in this patient population.
Main Methods:
- A prospective, cross-sectional study involving 67 pediatric patients (aged 8-19) with repaired Tetralogy of Fallot.
- Comparison of muscle strength (handgrip, maximal voluntary isometric contraction, dynamic strength) with two healthy pediatric cohorts.
- Analysis of correlations between muscle strength parameters and peak oxygen uptake (exercise capacity in mL/min) using univariate and multivariate models.
Main Results:
- Patients with repaired Tetralogy of Fallot demonstrated significantly reduced grip strength (z-score -1.5±1.2) and total muscle strength (z-score -0.9±1.3) compared to healthy peers.
- Dynamic muscle strength was also reduced, although running, speed, and agility remained within normal ranges.
- Strong correlations were found between muscle strength (grip and total) and peak oxygen uptake (r=0.83 and r=0.88, respectively).
- Multivariate analyses confirmed that total muscle strength and forced vital capacity independently correlated with peak oxygen uptake.
Conclusions:
- Pediatric patients with repaired Tetralogy of Fallot exhibit diminished muscle strength.
- Reduced muscle strength is a significant factor correlating with lower exercise performance and peak oxygen uptake in this population.
- These findings underscore the importance of addressing muscle strength deficits in the rehabilitation and management of children with repaired Tetralogy of Fallot.
More Related Videos
07:10Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
9.8K
07:40Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
Published on: October 10, 2019
7.3K
Related Concept Videos
01:27Exercise and Muscle Performance
1.5K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.5K
01:17Exercise and Cardiac Output
1.1K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.1K
01:20Exercise and Cardiovascular Response
879
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
879
01:22Mitral Stenosis I: Introduction
19
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
19
01:26Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
17
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
17