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Metastatic secondary gliosarcoma: patient series
Shivani Baisiwala1, Myungjun Ko1, Humza Zubair1
11Department of Neurosurgery and.
Journal of Neurosurgery. Case Lessons
|May 23, 2023
Summary
Metastatic secondary gliosarcoma, a rare cancer evolving from glioblastoma, is highly aggressive. This study details 7 cases and a literature review, confirming a poor prognosis for this rare central nervous system malignancy.
Area of Science:
- Neuro-oncology
- Cancer Metastasis
- Pathology
Background:
- Gliosarcoma is a rare, highly malignant central nervous system cancer.
- Secondary gliosarcoma evolves from glioblastoma (WHO grade IV) and can metastasize.
- Limited data exists on metastatic secondary gliosarcoma.
Purpose of the Study:
- To characterize clinical, imaging, and pathological features of metastatic secondary gliosarcoma.
- To conduct a systematic review of metastases in secondary gliosarcoma.
- To evaluate the prognosis of this rare condition.
Main Methods:
- Retrospective analysis of 7 patients with secondary gliosarcoma and metastases.
- Systematic literature review on metastatic secondary gliosarcoma.
- Review of clinical, imaging, and pathological data.
Main Results:
- Seven patients with glioblastoma developed secondary gliosarcoma with metastases.
- The institutional series and literature review indicate aggressive disease.
- Metastatic secondary gliosarcoma is associated with a poor prognosis.
Conclusions:
- Metastatic secondary gliosarcoma is a rare but aggressive entity.
- The disease carries a poor prognosis.
- Further research is needed to understand and treat metastatic secondary gliosarcoma.
