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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Cells of the Epidermis01:24

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Related Experiment Video

Updated: Jul 29, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
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Spiny Keratoderma in Association with Melanoma.

Tatsiana Pukhalskaya1, Thaddeus W Mully1, Maria L Wei2

  • 1Department of Pathology, Dermatopathology and Oral Pathology Services, University of California San Francisco, San Francisco, CA 94115, USA.

Dermatopathology (Basel, Switzerland)
|May 23, 2023
PubMed
Summary

Spiny keratoderma (SK) is a rare skin condition with distinct keratin spines. This case highlights a potential association between SK and melanoma in situ, warranting further investigation.

Keywords:
filiform hyperkeratosisfollicular hyperkeratosismelanoma in situporokeratosis punctata palmaris et plantarispunctate porokeratosisspiny keratoderma

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Spiny keratoderma (SK) is a rare condition characterized by hyperkeratotic spines on the palms and soles.
  • SK presents in various forms, including familial, sporadic, post-inflammatory, and paraneoplastic.
  • Previous reports suggest a possible link between SK and melanoma, but this association requires further study.

Observation:

  • This report details a case of spiny keratoderma in a patient with a recent history of melanoma in situ.
  • The patient presented with characteristic 1-2 mm keratin spines on the palms and soles.

Findings:

  • The case contributes to the limited data on the co-occurrence of spiny keratoderma and melanoma.
  • Histological examination confirmed the characteristic hyperkeratosis forming the 'spines' of SK.

Implications:

  • This case underscores the importance of considering potential associations between dermatological conditions like SK and underlying malignancies.
  • Further research into the relationship between spiny keratoderma and melanoma may improve diagnostic and management strategies.
  • Understanding this rare co-occurrence can enhance clinical awareness and patient care in dermatology and oncology.