Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality of Life Following Modified Radical Mastectomy for Breast Cancer in Haiti.

JCO global oncology·2026
Same author

Survival outcomes of cervical cancer patients treated with external beam radiotherapy boost in Rwanda.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Liquid Biopsy in Primary CNS Tumors: Bridging Biology, Technology, and Clinical Care.

Molecular diagnosis & therapy·2026
Same author

Uncovering novel germline variants associated with testicular germ cell tumors by exome sequencing.

NAR cancer·2026
Same author

Reporting Standards and Quality Assurance Methods for Pancreatoduodenectomy in Randomised Controlled Trials: A Structured Narrative Review.

Journal of clinical medicine·2026
Same author

The OligoPanc project: an interdisciplinary expert consensus statement on oligometastatic pancreatic cancer.

The Lancet. Oncology·2026

Related Experiment Video

Updated: Jun 17, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.9K

Germline Testing Around the Globe: Challenges in Different Practice Settings.

Sana Al-Sukhun1, Yazan Masannat2,3, Talia Wegman-Ostrosky4

  • 1Al Hyatt Oncology Practice, Amman, Jordan.

American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting
|May 23, 2023
PubMed
Summary

Heredity significantly contributes to cancer risk, with 16% of cases being heritable. Addressing germline testing globally requires collaboration and tailored approaches for prevention and early detection, especially in low-resource settings.

More Related Videos

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
14:45

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Published on: August 6, 2014

16.4K
Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.1K

Related Experiment Videos

Last Updated: Jun 17, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.9K
Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
14:45

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Published on: August 6, 2014

16.4K
Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.1K

Area of Science:

  • Oncology
  • Genetics
  • Public Health

Background:

  • Cancer represents a growing global health challenge.
  • Heredity plays a crucial role in cancer development, with 16% of cases linked to heritable factors.
  • Low- and middle-income countries face a disproportionate burden of hereditary cancers.

Purpose of the Study:

  • To highlight the significance of hereditary cancer and germline genetic variants in cancer care.
  • To identify challenges in implementing germline testing globally.
  • To emphasize the need for tailored strategies for prevention, early detection, and treatment.

Main Methods:

  • Review of global cancer statistics and hereditary cancer prevalence.
  • Analysis of factors contributing to cancer risk, including genetic and environmental influences.
  • Examination of barriers to germline testing in clinical settings worldwide.

Main Results:

  • Approximately 16% of cancer cases are heritable, totaling 2.9 million annually.
  • Low- and middle-income countries account for at least two-thirds of hereditary cancer diagnoses.
  • Significant obstacles hinder the widespread clinical implementation of germline testing.

Conclusions:

  • Hereditary cancer presents opportunities for targeted prevention, early detection, and novel therapies.
  • Global collaboration and knowledge exchange are vital to overcome implementation barriers.
  • Adapting guidelines to local resources is essential for addressing diverse societal needs in hereditary cancer care.