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Hyperthermia-induced pulmonary edema.

K Y Mustafa, W M Selig, K E Burhop

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |June 1, 1986
    PubMed
    Summary
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    Elevated temperatures (43-45°C) significantly increase pulmonary edema and albumin clearance in isolated lungs, indicating heat-induced lung injury. This study highlights temperature as a critical factor in lung vascular permeability.

    Area of Science:

    • Physiology
    • Pathology

    Background:

    • Pulmonary edema and altered vascular permeability are critical in lung injury.
    • The direct impact of elevated temperatures on lung vascular integrity requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of hyperthermia on pulmonary edema formation.
    • To assess the impact of elevated temperatures on transendothelial albumin clearance.

    Main Methods:

    • Isolated perfused guinea pig lungs were used to model lung injury.
    • Bovine pulmonary arterial endothelial cells on a membrane assessed transendothelial permeability.
    • Lung wet-to-dry weight ratios and pulmonary capillary pressure were measured.
    • 125I-albumin clearance was quantified across endothelial cell monolayers.

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    Main Results:

    • Perfusion at 43°C and 45°C significantly increased lung wet-to-dry weight ratios, indicating edema formation.
    • Elevated temperatures (45°C) led to a threefold increase in transendothelial albumin clearance.
    • Increased temperature did not affect the permeability of the underlying membrane alone.

    Conclusions:

    • Hyperthermia (≥43°C) induces pulmonary edema and increases lung vascular permeability.
    • Elevated temperatures directly impair endothelial barrier function, contributing to lung injury.
    • Temperature is a significant factor influencing lung vascular integrity and edema formation.