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Abnormal plasma catecholamine responses in acromegalics.

G R Van Loon

    The Journal of Clinical Endocrinology and Metabolism
    |May 1, 1979
    PubMed
    Summary
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    Acromegaly patients do not show expected decreases in plasma catecholamines after bromocriptine or LRH treatment. This suggests potential central nervous system catecholamine neuron dysfunction in acromegaly.

    Area of Science:

    • Neuroendocrinology
    • Endocrinology
    • Neuroscience

    Background:

    • Acromegaly is a hormonal disorder characterized by excessive growth hormone production.
    • Catecholamines, including dopamine, norepinephrine, and epinephrine, play crucial roles in physiological regulation.
    • Previous studies indicate that bromocriptine and LRH can modulate catecholamine levels in healthy individuals.

    Purpose of the Study:

    • To investigate the plasma catecholamine responses to bromocriptine and LRH in patients with acromegaly.
    • To compare these responses with those observed in normal men and non-acromegalic endocrine control subjects.
    • To explore potential central nervous system mechanisms underlying catecholamine regulation in acromegaly.

    Main Methods:

    • Seven acromegalic patients were administered bromocriptine (2.5 mg orally) or LRH (100 microgram iv).

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  • Plasma concentrations of dopamine, norepinephrine, and epinephrine were measured before and after drug administration.
  • Basal plasma catecholamine levels were also assessed in normal men and endocrine control groups.

    • Main Results:

    • Acromegalic subjects failed to exhibit the marked decrease in plasma catecholamines observed in normal men following bromocriptine or LRH administration.
    • No significant difference was found in mean basal plasma catecholamine concentrations among acromegalic patients, normal men, and control subjects.
    • The blunted catecholamine response was observed in 4 out of 4 patients for bromocriptine and 3 out of 4 for LRH.

    Conclusions:

    • The findings suggest that bromocriptine and LRH may suppress plasma catecholamines via central catecholamine neurons.
    • Acromegalic patients exhibit disordered catecholamine neuron function in the brain, leading to an impaired response to these agents.
    • This study highlights a potential neuroendocrine link between acromegaly and central catecholamine dysregulation.