Liquid chromatographic determination of chlorpropamide in tablet dosage forms: collaborative study

A reverse-phase liquid chromatographic method was developed for determining chlorpropamide in tablet dosage forms. Linearity was established over the range 0.2-2.0 micrograms at a wavelength of 240 nm. The Associate Referee obtained a mean recovery for a synthetic tablet mixture of 99.2%, with a relative standard deviation (RSD) of 1.41. For an authentic tablet mixture, collaborators obtained a mean recovery of 99.6% with an RSD of 0.60%. RSDs were 1.24% for 250 mg/tablet commercial product and also for 100 mg/tablet commercial product. The method has been adopted official first action.