Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

27.9K
Overview
27.9K
Allergic Drug Reactions01:27

Allergic Drug Reactions

903
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
903
Hypersensitivities01:30

Hypersensitivities

821
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
821
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

469
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
469
Cross-reactivity00:42

Cross-reactivity

31.4K
Overview
31.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dupilumab in patients with cold urticaria: Results from a phase 3 trial.

The journal of allergy and clinical immunology. Global·2026
Same author

Matching-adjusted indirect comparison analysis of omalizumab versus dupilumab in patients with chronic spontaneous urticaria.

The journal of allergy and clinical immunology. Global·2026
Same author

Dupilumab in Patients With Chronic Spontaneous Urticaria: Phase 3 LIBERTY-CSU CUPID Randomized Clinical Trials.

JAMA dermatology·2026
Same author

Systemic Treatments for Chronic Spontaneous Urticaria: Anti-IgE and Beyond.

The journal of allergy and clinical immunology. In practice·2026
Same author

An opportunity to improve the quality of care for patients with chronic spontaneous urticaria: A reimagined 3-step real-world study protocol.

The journal of allergy and clinical immunology. Global·2026
Same author

Emerging IgE and non-IgE targeted therapies for chronic urticaria.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025
Same journal

Sustained clinical remission and relapse of severe eosinophilic asthma following long-term mepolizumab treatment.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same journal

Distinct peripheral coagulation-fibrinolysis profiles in eosinophilic and non-eosinophilic chronic rhinosinusitis.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same journal

Ultra-short recombinant Art v 1 immunotherapy induces rapid immune modulation in mugwort allergy: A Phase I trial.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same journal

Distinct allergen-specific T cell receptor clonotypes drive divergent immune programs in a cloned mouse model of atopic dermatitis.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same journal

Short-chain fatty acids modulate the development and the cell surface molecule expression of DCs by epigenetic regulation.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same journal

Skin symptoms during the pollen seasons and their association with the severity of seasonal allergic rhinitis in Yamanashi, Japan.

Allergology international : official journal of the Japanese Society of Allergology·2026
See all related articles

Related Experiment Video

Updated: Jul 29, 2025

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

8.3K

Urticaria and basophils.

Sarbjit S Saini1

  • 1Division of Allergy & Clinical Immunology, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Room 2B 71B, Baltimore, MD, 21224, USA.

Allergology International : Official Journal of the Japanese Society of Allergology
|May 23, 2023
PubMed
Summary
This summary is machine-generated.

Chronic spontaneous urticaria (CSU) involves skin mast cells and blood basophils. Altered basophil function and numbers in CSU may serve as a disease biomarker.

Keywords:
BasophilsFceRIHivesIgEUrticaria

More Related Videos

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

33.7K
Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.5K

Related Experiment Videos

Last Updated: Jul 29, 2025

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

8.3K
Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

33.7K
Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.5K

Area of Science:

  • Immunology
  • Dermatology
  • Allergy

Background:

  • Chronic spontaneous urticaria (CSU) is a prevalent skin condition with unknown causes in most cases.
  • CSU symptoms and pathology resemble allergic reactions, suggesting IgE receptor activation on skin mast cells.
  • Evidence indicates a role for blood basophils in CSU, with their numbers decreasing during active disease.

Purpose of the Study:

  • To investigate the role of blood basophils in the pathogenesis of CSU.
  • To explore the IgE receptor-mediated degranulation patterns of basophils in CSU patients.
  • To assess the potential of basophil alterations as biomarkers for CSU.

Main Methods:

  • Analysis of blood basophil counts and phenotypes in active CSU patients and remission.
  • Evaluation of IgE receptor-mediated degranulation in basophils.
  • Assessment of IgE receptor signaling molecule expression in basophils.

Main Results:

  • Blood basophilopenia observed in active CSU, with basophil recruitment to skin lesions.
  • Two distinct basophil phenotypes with altered IgE receptor-mediated degranulation identified, improving in remission.
  • Changes in IgE receptor signaling molecule expression correlate with altered basophil degranulation in active CSU.

Conclusions:

  • Blood basophils play a significant role in CSU pathogenesis.
  • Altered basophil phenotypes and counts in CSU patients show potential as reliable biomarkers.
  • Targeting IgE in CSU therapy is supported by these findings, highlighting basophil involvement.