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Association of C-reactive protein gene polymorphisms with the risk of ischemic stroke: A systematic review and

Wei Chen1,2,3, Xiaomin Zhu4, Yueqiang Hu2

  • 1Graduate School of Jiangxi University of Chinese Medicine, Nanchang, China.

Brain and Behavior
|May 23, 2023
PubMed

Insights

C-reactive protein (CRP) gene variants show no significant association with ischemic stroke (IS) risk. Further research is needed for specific CRP gene polymorphisms like rs1800947 in certain populations.

Area of Science:

  • Genetics and Molecular Biology
  • Neurology
  • Cardiovascular Research

Background:

  • Ischemic stroke (IS) is a complex condition influenced by genetic and environmental factors.
  • Previous studies on C-reactive protein (CRP) gene polymorphisms and IS risk have yielded inconsistent results.
  • This meta-analysis aimed to clarify the association between CRP gene variants and IS risk.

Approach:

  • A comprehensive literature search was conducted across major databases (PubMed, EMBASE, Cochrane Library, Google Scholar) from 1950 to 2022.
  • Twelve case-control studies involving 3880 IS cases and 5233 controls were analyzed.
  • Odds ratios (OR) with 95% Confidence Intervals (CIs) were calculated using fixed/random effect models for five CRP gene polymorphisms (rs1800947, rs1130864, rs3093059, rs2794521, rs1205).

Key Points:

  • No significant association was found between CRP gene polymorphisms rs1130864, rs3093059, rs2794521, and rs1205 and IS risk across all models.
  • A trend towards significant association was observed for rs1800947 under dominant, recessive, and allelic models.
  • A protective association was noted for rs1130864 under the dominant model and for rs3093059 under the allelic model.

Conclusions:

  • The analyzed CRP gene variants (rs1800947, rs1130864, rs3093059, rs2794521, rs1205) are not definitively linked to ischemic stroke risk.
  • Further investigation into the rs1800947 polymorphisms within specific populations is warranted.
Abstract

Keywords:
C-reactive proteinMeta-analysisPolymorphismcase-control studyischemic stroke

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