Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lester Packer and Vitamin E: Editorial.

Regina Brigelius-Flohé1

  • 1German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany.

Antioxidants & Redox Signaling
|May 24, 2023
PubMed
Summary

Professor Lester Packer

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vitamin E research: Past, now and future.

Free radical biology & medicine·2021
Same author

Regulatory Phenomena in the Glutathione Peroxidase Superfamily.

Antioxidants & redox signaling·2019
Same author

Selenium and selenoproteins in (redox) signaling, diseases, and animal models - 200 year anniversary issue.

Free radical biology & medicine·2018
Same author

Selenium research in biochemistry and biophysics - 200 year anniversary issue.

Biochimica et biophysica acta. General subjects·2018
Same author

Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems.

Food & function·2016
Same author

Selenoprotein Gene Nomenclature.

The Journal of biological chemistry·2016

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Exercise Physiology

Background:

  • Pioneered freeze fracture electron microscopy for visualizing biological membranes.
  • Investigated the role of vitamin E (tocopherols and tocotrienols) in cellular structures.
  • Initiated exercise biology research by studying tocol effects on animals.

Discussion:

  • Examined vitamin E's impact on mitochondrial integrity and membrane stabilization.
  • Explored intermembrane exchange mechanisms involving tocols.
  • Investigated vitamin E's influence on redox signaling and gene expression.

Key Insights:

  • Demonstrated vitamin E loss and muscle mitochondria damage following exhaustive exercise.
  • Identified specific activities of various tocols, including tocotrienols.
  • Highlighted vitamin E's fundamental role in membrane protection and cellular function.

Outlook:

  • Further research into the precise mechanisms of vitamin E's biomembrane protection.
  • Continued exploration of vitamin E's involvement in redox signaling and gene regulation.
  • Leveraging Packer's foundational work to advance understanding of vitamin E's health implications.
Keywords:
biomembranefreeze etchinggene expressionintermembrane traffickingsignalingspecific activitytocols

Related Experiment Videos