Infection, nutritional status, and body composition: Associations at birth and 6 months postnatally in Soweto, South
Douglas J Momberg1,2, Rachel Bell1, Shane A Norris2,3
1Department of Archaeology, Biological Anthropology, University of Cambridge, Cambridge, UK.
Insights
Infant infections in the first six months impact body composition, reducing fat mass (FM) and fat mass index (FMI) while increasing fat-free mass (FFM). Preventing infection through improved sanitation is crucial for infant health.
Area of Science:
- Pediatrics
- Nutritional Science
- Public Health
Background:
- Infection significantly impacts infant growth, but its effect on body composition is understudied.
- Early life infections may alter developmental trajectories during a critical period of plasticity.
Purpose of the Study:
- To investigate the association between early-life morbidity and infant body composition at six months.
- To explore the relationship between infection, nutritional status, and body composition in infants.
Main Methods:
- Hierarchical regression analysis was used to examine associations.
- Data from 156 healthy infants in Soweto, South Africa, from birth to six months were analyzed.
- A composite morbidity index was created from cumulative symptom tallies.
Main Results:
- Morbidity was linked to lower fat mass index (FMI) and fat mass (FM), but higher fat-free mass (FFM) at six months.
- No significant associations were found between morbidity and fat-free mass index (FFMI), height-for-age (HAZ), or weight-for-height (WHZ).
- Higher birthweight correlated with increased FFM, HAZ, and WHZ; improved sanitation was associated with higher HAZ.
Conclusions:
- Early-life infections negatively affect infant body composition, specifically reducing fat mass.
- Public health strategies should prioritize infection prevention in infants, emphasizing access to safe sanitation facilities.
Introduction:
The impact of infection on infant nutritional status, body size, and growth is well documented. However, research into the impact of infection on infant body composition is limited. Greater understanding is, therefore, needed on the effects of infection in early life.
Methods:
Associations between a composite morbidity index consisting of the sum of the cumulative tallies for a range of symptoms representing infection and morbidity in the infants and nutritional status (height-for-age (HAZ), and weight-for-height (WHZ)), and body composition (fat-free mass (FFM), fat mass (FM), fat-free mass index (FFMI), and fat mass index (FMI)) at 6 months of age were investigated using hierarchical regression analysis.
Results:
The sample comprised data between birth and 6 months postnatally, of 156 infants who were a priori born healthy in Soweto, South Africa. Morbidity, over the cumulative period of birth to 6 months, was associated with lower FMI (β = -1.77) and lower FM (β = -0.61), and conversely with higher FFM (β = 0.94), in infants at 6 months. No associations were found between the morbidity index and FFMI, HAZ, and WHZ. Increased birthweight was associated with a higher FFM (β = 0.66), HAZ (β = 1.14), and WHZ (β = 0.87). Finally, safely managed sanitation facilities, representative of reduced environmental exposure to fecal-oral transmission pathways were associated with a higher HAZ (β = 1.21).
Discussion:
Reduction in FMI and FM and exposure to inflammatory cytokines associated with mounting an immune response could alter phenotypic trajectories during to this period of plasticity. From a public health perspective, these results imply that it is important to intensify efforts to prevent infection in infants in the first 6 months postnatally, and that these efforts should concentrate on access to safely managed sanitation facilities.
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