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Systemic immune-inflammation index associated with contrast-induced nephropathy after elective percutaneous coronary

Xiao Ma1, Changhua Mo, Yujuan Li

  • 1Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University & Guangxi Key Laboratory Base of Precision Medicine in Cardiocerebrovascular Diseases Control and Prevention & Guangxi Clinical Research Center for Cardiocerebrovascular Diseases, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.

Coronary Artery Disease
|May 24, 2023
PubMed

Insights

Elevated systemic immune-inflammation index (SII) is a risk factor for contrast-induced nephropathy (CIN) after elective percutaneous coronary intervention (PCI). This association is particularly strong in male patients, highlighting SII as a potential predictive biomarker.

Area of Science:

  • Cardiology
  • Nephrology
  • Immunology

Background:

  • Elevated systemic immune-inflammation index (SII) is linked to coronary heart disease and adverse outcomes.
  • The association between SII and contrast-induced nephropathy (CIN) in patients undergoing elective percutaneous coronary intervention (PCI) remains unclear.

Purpose of the Study:

  • To investigate the relationship between SII and the development of CIN in patients undergoing elective PCI.
  • To identify SII as a potential predictive biomarker for CIN in this patient population.

Main Methods:

  • Retrospective study of 241 patients undergoing elective PCI between March 2018 and July 2020.
  • CIN defined by serum creatinine increase (≥0.5 mg/dL or ≥25% from baseline) within 48-72 hours post-PCI.
  • Correlation analysis, multivariate logistic regression, and receiver operating characteristic (ROC) curve analysis were performed.

Main Results:

  • Patients with CIN exhibited significantly higher SII levels compared to those without.
  • SII positively correlated with uric acid and negatively with estimated glomerular filtration rate.
  • Elevated log2(SII) was an independent risk factor for CIN (OR=2.686), especially in males (OR=3.669).
  • ROC analysis indicated an SII cutoff of 586.19 for predicting CIN with 75% sensitivity and 54.2% specificity.

Conclusions:

  • Elevated SII is an independent risk factor for CIN development in patients undergoing elective PCI.
  • The association between SII and CIN is more pronounced in male patients.
  • SII may serve as a valuable predictive biomarker for CIN in elective PCI patients, particularly males.

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