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Published on: January 9, 2015
White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive
Gwyneth Zai1,2,3, Clement C Zai1,2,3,4,5, Paul D Arnold6,7
1Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health.
Abstract:
The myelin oligodendrocyte glycoprotein ( MOG ) gene plays an important role in myelination and has been implicated in the genetics of white matter changes in obsessive-compulsive disorder (OCD). We examined the association between variations of two microsatellite markers across MOG for association and total white matter volume as measured using volumetric MRI in 37 pediatric OCD patients 7-18 years. We compared white matter volumes between microsatellite allele groups using analysis of covariance with covariates of age, gender, and total intracranial volume. After controlling for multiple comparisons, a significant relationship was detected between MOG (TAAA)n and increased total white matter volume ( P = 0.018-0.028). Although preliminary, our findings provide further support for the involvement of MOG in OCD.
Insights
This study found a link between myelin oligodendrocyte glycoprotein (MOG) gene variations and increased white matter volume in pediatric obsessive-compulsive disorder (OCD). These findings suggest MOG
Area of Science:
- Neurogenetics
- Neuroimaging
- Pediatric Psychiatry
Background:
- The myelin oligodendrocyte glycoprotein (MOG) gene is crucial for myelination.
- MOG gene variations have been linked to white matter alterations in obsessive-compulsive disorder (OCD).
Purpose of the Study:
- To investigate the association between MOG gene microsatellite markers and total white matter volume in pediatric OCD patients.
- To explore the genetic underpinnings of white matter changes in OCD.
Main Methods:
- Volumetric magnetic resonance imaging (MRI) was used to measure total white matter volume.
- Analysis of covariance was employed to compare white matter volumes between different MOG microsatellite allele groups, controlling for age, gender, and total intracranial volume.
- 37 pediatric OCD patients aged 7-18 years were included in the study.
Main Results:
- A significant association was detected between the MOG (TAAA)n microsatellite marker and increased total white matter volume (P = 0.018–0.028) after adjusting for multiple comparisons.
- This suggests a potential genetic influence of MOG on white matter structure in pediatric OCD.
Conclusions:
- Preliminary findings support the involvement of the MOG gene in the pathophysiology of obsessive-compulsive disorder.
- Further research is warranted to elucidate the role of MOG in OCD and associated white matter abnormalities.
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