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Biologics for severe asthma-Which, when and why?
Peer Ameen Shah1, Chris Brightling1
1Institute for Lung Health, NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.
Respirology (Carlton, Vic.)
|May 24, 2023
Summary
Biologics offer new hope for severe asthma, particularly type-2 mediated cases, by potentially altering disease course and inducing remission. However, unmet needs persist for many severe asthma patients.
Area of Science:
- Pulmonology
- Immunology
- Pharmacology
Background:
- Asthma affects 350 million globally, with 5-10% experiencing severe disease.
- Severe asthma is linked to significant morbidity and high healthcare costs.
- Current management aims for disease control and reduced corticosteroid toxicity.
Purpose of the Study:
- To review the pathogenesis and heterogeneity of asthma.
- To discuss current and future biologic therapies for severe asthma.
- To provide guidance on biologic selection, response assessment, and treatment adjustments.
Main Methods:
- Review of asthma pathogenesis and phenotyping.
- Analysis of licensed and emerging biologic agents.
- Discussion of clinical strategies for biologic therapy.
Main Results:
- Biologics have transformed severe asthma care, especially for type-2 inflammation.
- Potential exists to alter disease trajectory and achieve remission.
- Substantial unmet needs remain despite biologic advancements.
Conclusions:
- Biologics represent a significant advancement in severe asthma management.
- Personalized approaches are crucial for optimizing biologic therapy.
- Continued research is needed to address remaining unmet needs in severe asthma.
Keywords:
asthmaasthma controlbiologicsbiologics switchingbiomarkersexacerbationsremissionsevere asthmaMore Related Videos
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