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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
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Interaction Between SARS-CoV-2 and Pathogenic Bacteria

Parvindokht Fazel1,2, Hamid Sedighian3, Elham Behzadi4

  • 1Department of Microbiology, Fars Science and Research Branch, Islamic Azad University, Eqlid, Fars, Iran.

Current Microbiology
|May 24, 2023
PubMed

Insights

Bacterial co-infections and secondary bacterial infections are critical risk factors for COVID-19 severity and mortality. This review summarizes bacterial co-infections in respiratory viral infections, particularly SARS-CoV-2.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes COVID-19, a global health threat.
  • Respiratory infections increase susceptibility to co-infections, worsening disease severity and mortality.
  • Bacterial co-infections are significant risk factors for COVID-19 severity and mortality.

Purpose of the Study:

  • To review bacterial co-infection and secondary bacterial infection in respiratory viral infections.
  • To highlight the impact of bacterial co-infections on COVID-19 outcomes.

Main Methods:

  • Literature review of bacterial co-infection in respiratory viral infections.
  • Focus on studies investigating co-infections in SARS-CoV-2 patients.

Main Results:

  • Viral respiratory infections, including COVID-19, can lead to bacterial pneumonia.
  • Bacterial co-infections may contribute to mortality in some COVID-19 patients.
  • Antibiotics are used to manage bacterial co-infections in SARS-CoV-2 patients.

Conclusions:

  • Bacterial co-infection is a critical factor influencing COVID-19 severity and mortality.
  • Understanding and managing bacterial co-infections is crucial for improving patient outcomes in viral respiratory infections.

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