Related Experiment Video
Updated: Jul 29, 2025
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
20.0K
Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review.
Heba M Bintalib1,2,3, Annick van de Ven4, Joseph Jacob1,5
1University College London (UCL) Respiratory, University College London, London, United Kingdom.
Frontiers in Immunology
|May 24, 2023
Summary
Diagnostic tests for Common Variable Immunodeficiency-related Interstitial Lung Disease (CVID-ILD) lack evidence-based guidelines. This review assesses diagnostic utility and risks, highlighting the need for consensus criteria for CVID-ILD management.
Area of Science:
- Pulmonology
- Immunology
- Radiology
Background:
- Common Variable Immunodeficiency-related Interstitial Lung Disease (CVID-ILD) affects up to 20% of CVID patients, stemming from immune dysregulation.
- Current diagnostic and management strategies for CVID-ILD lack evidence-based guidelines.
Approach:
- A systematic review was conducted using EMBASE, MEDLINE, PubMed, and Cochrane databases.
- Included studies reported on the diagnosis of ILD in CVID patients.
- Evaluated the utility and risks of various diagnostic tests.
Key Points:
- Radiology, particularly High-Resolution Computed Tomography (HRCT), is frequently used to detect CVID-ILD.
- Lung biopsy, especially surgical biopsy, provides more conclusive results than trans-bronchial biopsy (TBB).
- Pulmonary function tests show variable results, often indicating a restrictive pattern and reduced gas transfer.
Conclusions:
- There is an urgent need for consensus diagnostic criteria for CVID-ILD.
- International collaboration is underway to develop diagnostic and management guidelines for CVID-ILD.
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