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Probiotics on chronic urticaria: A randomized clinical trial study.

Abbas Dabaghzadeh¹, Javad Ghaffari², Siavash Moradi³

¹Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Caspian Journal of Internal Medicine

|May 24, 2023

Summary

Probiotic supplements, when combined with antihistamines, significantly reduce chronic urticaria activity. This study found no significant improvement in patients' quality of life despite reduced urticaria symptoms.

Keywords:

Chronic urticaria Histamine antagonists Probiotics Therapeutics

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Area of Science:

Dermatology
Microbiology
Clinical Trials

Background:

Urticaria is a prevalent itchy skin condition marked by swelling and erythema.
Chronic resistant urticaria often requires advanced treatment strategies.
Existing treatments for urticaria have varying degrees of efficacy.

Purpose of the Study:

To assess the clinical impact of probiotic supplementation in patients with chronic, treatment-resistant urticaria.
To evaluate the efficacy of probiotics as an adjunct therapy for urticaria.
To determine if probiotics can improve urticaria activity and patient quality of life.

Main Methods:

A four-way blind randomized clinical trial was conducted from June 2019 to June 2020.
Patients with chronic urticaria unresponsive to antihistamines were enrolled.
Intervention: antihistamine (cetirizine) + probiotics (femilact capsule) vs. Control: antihistamine (cetirizine) + placebo for 8 weeks.

Main Results:

Both groups showed reduced Urticarial Activity for 7 Days (UAS7) scores.
The intervention group experienced a significantly greater reduction in UAS7 scores (9.6±6.4) compared to the control group (12.7±8.1) (P=0.036).
No significant difference in Dermatology Life Quality Index (DLQI) scores was observed between groups after 8 weeks (P=0.805).

Conclusions:

Probiotic consumption, alongside antihistamines, significantly enhances the management of urticaria activity.
Probiotics did not demonstrate a significant impact on the quality of life for patients with chronic urticaria in this study.
Further research may explore long-term effects and different probiotic strains for urticaria treatment.