Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A statistical method for assessing change in immunologic parameters in a patient.

J M Taylor, S Plaeger-Marshall, J L Fahey

    Journal of Clinical Immunology
    |May 1, 1986
    PubMed
    Summary

    This study introduces a statistical method to track changes in individual immune status over time using serial measurements. It helps determine if observed immune parameter shifts exceed normal variations, aiding clinical immunology assessments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India.

    AIDS research and treatment·2012
    Same author

    Continuing medical education on antiretroviral therapy in HIV/AIDS in India: needs assessment and impact on clinicians and allied health personnel.

    The National medical journal of India·2010
    Same author

    Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity.

    Proceedings of the National Academy of Sciences of the United States of America·2001
    Same author

    Idiopathic CD4+ T cell lymphocytopenia evolving to monoclonal immunoglobulins and progressive renal damage responsive to IL-2 therapy.

    Clinical immunology (Orlando, Fla.)·2001
    Same author

    Thalidomide in low intermittent doses does not prevent recurrence of human immunodeficiency virus-associated aphthous ulcers.

    The Journal of infectious diseases·2000
    Same author

    Cytokine gene expression occurs more rapidly in stimulated peripheral blood mononuclear cells from human immunodeficiency virus-infected persons.

    Clinical and diagnostic laboratory immunology·2000

    Area of Science:

    • Immunology
    • Biostatistics
    • Clinical Research

    Background:

    • Serial immunologic parameter measurements are vital for monitoring disease progression and treatment effects.
    • Detecting significant changes in immune status requires distinguishing true alterations from natural within-individual variation.

    Purpose of the Study:

    • To present a statistical method for analyzing serial immunologic data to identify significant changes in individuals.
    • To provide tools for clinical immunology to interpret changes in immune parameters effectively.

    Main Methods:

    • Utilized analysis of variance (ANOVA) assuming a normal distribution.
    • Calculated percentiles of the absolute difference between consecutive immunologic parameter values in a healthy cohort.
    • Developed methods for constructing interpretive tables and selecting appropriate change models (linear vs. logarithmic).

    Related Experiment Videos

    Main Results:

    • Established a statistically sound method to assess significant changes in individual immunologic parameters.
    • Provided a framework for creating practical tools for clinical interpretation of serial immune data.
    • Demonstrated the method's adaptability for various scenarios, including directional changes and multiple measurements.

    Conclusions:

    • The presented statistical approach enables robust detection of meaningful changes in immune status from serial measurements.
    • This method enhances the clinical utility of immunologic monitoring, supporting better patient management and therapeutic evaluation.