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Updated: Jul 29, 2025

Developing a Rat Model for Bipolar Disorder

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Discourse abilities in euthymic elderly patients with bipolar disorder: a preliminary study.

Maria Gabriela Valeriano¹, Renné Alegria¹, Orestes Vicente Forlenza¹

¹Universidade de São Paulo, Faculdade de Medicina, Departamento de Psiquiatria, Laboratório de Neurociências, São Paulo SP, Brazil.

Dementia & Neuropsychologia

|May 24, 2023

Summary

Elderly individuals with bipolar disorder (BD) showed subtle language differences in discourse tasks. These patients exhibited more cohesion errors and fewer thematic units in oral descriptions compared to controls.

Keywords:

Aged Bipolar Disorder Cognition Language Narration

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Published on: December 4, 2014

Area of Science:

Neuropsychology
Psycholinguistics
Geriatric Psychiatry

Background:

Cognitive impairment is recognized in euthymic bipolar disorder (BD) and elderly populations.
Language disturbances in BD are less understood, with existing research focusing on verbal fluency and semantics.
Discourse abilities in BD remain under-explored, necessitating further investigation.

Purpose of the Study:

To investigate and characterize discourse abilities in euthymic elderly individuals diagnosed with bipolar disorder (BD).

Main Methods:

A cohort of 19 euthymic elderly BD patients and a control group underwent cognitive assessments.
Participants completed oral and written descriptions of the Cookie Theft Picture.
Linguistic analysis focused on micro- and macrolinguistic features, with statistical comparisons using generalized linear models.

Main Results:

The BD group demonstrated a higher frequency of cohesion errors in both oral (p=0.016) and written (p=0.011) discourse.
BD patients produced fewer thematic units in oral discourse (p=0.027) compared to the control group.
Overall, minimal changes were observed in the descriptive discourse task for BD patients.

Conclusions:

Elderly BD patients exhibit specific alterations in discourse, notably increased cohesion errors and reduced thematic content.
These findings highlight subtle yet significant language challenges in the discourse of euthymic elderly BD individuals.
Further research is warranted to fully understand the impact of BD on complex language functions in aging populations.