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Related Experiment Videos

Histometry of normal thyroid in man.

R A Brown, M Al-Moussa, J Beck

    Journal of Clinical Pathology
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid volume changes with age, increasing in youth and declining in older adults. These changes are due to alterations in the size of individual thyroid acini, not their number.

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    Area of Science:

    • Endocrinology
    • Histopathology
    • Gerontology

    Background:

    • The aging process affects various organs, including the thyroid gland.
    • Understanding age-related changes in thyroid morphology is crucial for accurate interpretation of diagnostic imaging and histopathology.

    Purpose of the Study:

    • To objectively assess age-related changes in thyroid volume and histological components.
    • To investigate the relationship between thyroid volume, acinar size, and age.

    Main Methods:

    • Collected thyroids from 107 patients without endocrine disease history at necropsy.
    • Utilized robust smooth curve fitting for objective assessment of age-related volume changes.
    • Measured volume proportions of histological components and acinar surface area.

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    Main Results:

    • Thyroid volume increases during childhood/adolescence, stabilizes in young adults, and declines in older individuals.
    • Age-related thyroid volume changes are primarily due to alterations in individual acinar size, not the total number of acini.
    • Microscopic nodules in normal thyroids increase in prevalence with age.

    Conclusions:

    • Thyroid volume changes with age are mainly driven by variations in acinar size.
    • The prevalence of microscopic nodules in the thyroid increases in older populations.
    • Robust curve fitting provides objective assessment of age-related thyroid volume dynamics.