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Related Experiment Video

Updated: Jul 29, 2025

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

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Exploring the split hand phenomenon with the neurophysiological index.

Cláudia Santos Silva1, Michael Swash2, Mamede de Carvalho1

  • 1Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa-Norte, Lisbon, Portugal; Faculdade de Medicina- Instituto de Medicina Molecular, Universidade de Lisboa, Lisbon, Portugal.

Neurophysiologie Clinique = Clinical Neurophysiology
|May 24, 2023
PubMed
Summary
This summary is machine-generated.

Neurophysiological indices in hand muscles, including compound muscle action potential (CMAP) and F-wave measurements, show age-related differences. These findings are important for diagnosing motor neuron diseases.

Keywords:
AgeAmyotrophic lateral sclerosisCompound muscle action potentialNeurophysiological indexSplit hand

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Area of Science:

  • Neurophysiology
  • Neurology
  • Biomedical Engineering

Background:

  • Age-related changes in peripheral nerve function are common.
  • Understanding these changes is crucial for accurate clinical diagnosis, especially in neurological disorders.
  • Standard neurophysiological tests may be influenced by age, necessitating age-adjusted interpretation.

Purpose of the Study:

  • To investigate age-dependent neurophysiological changes in three key hand muscles.
  • To evaluate the utility of a novel split-hand index (SHI) in reflecting these age-related alterations.
  • To determine the relevance of these findings for diagnosing motor neuron diseases.

Main Methods:

  • Studied 164 subjects across various age groups.
  • Measured neurophysiological index (NI) using compound muscle action potential (CMAP) amplitude, distal motor latency, and F-wave frequency for abductor pollicis brevis (APB), first dorsal interosseous (FDI), and abductor digiti minimi (ADM) muscles.
  • Calculated split-hand indices based on CMAP amplitude (SHI_CMAP) and NI (SHI_NI).

Main Results:

  • Significant differences in all measured neurophysiological parameters were observed between age groups (p<0.001).
  • Hand muscle NIs demonstrated a clear age dependency.
  • Both SHI_NI and SHI_CMAP were found to be age-dependent.

Conclusions:

  • Neurophysiological measurements of hand muscles, including NI and SHI, are significantly influenced by age.
  • These age-dependent neurophysiological changes have potential implications for the diagnostic accuracy of motor neuron diseases.
  • Age-adjusted reference values may be necessary for precise interpretation of neurophysiological data in clinical settings.