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Comorbid asthma decreased the risk for COVID-19 mortality in the United Kingdom: Evidence based on a meta-analysis

Liqin Shi1, Yadong Wang2, Xueya Han1

  • 1Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, 450001 Henan Province, China.

International Immunopharmacology
|May 24, 2023
PubMed

Insights

Patients with asthma had a lower risk of death from coronavirus disease 2019 (COVID-19) in the UK. This finding highlights the importance of continuing routine asthma care during the COVID-19 pandemic.

Area of Science:

  • Epidemiology
  • Public Health

Background:

  • Investigate the impact of comorbid asthma on mortality risk in COVID-19 patients.
  • Assess the association between asthma and COVID-19 mortality within the United Kingdom population.

Approach:

  • Conducted a quantitative meta-analysis of 24 eligible studies.
  • Included 1,209,675 COVID-19 patients to estimate the pooled odds ratio (OR) using a random-effects model.
  • Performed sensitivity, meta-regression, subgroup, and publication bias analyses (Begg's and Egger's).

Key Points:

  • Comorbid asthma was significantly associated with a decreased risk for COVID-19 mortality (pooled OR = 0.81, 95% CI: 0.71-0.93).
  • High heterogeneity (I² = 89.2%) was observed, but meta-regression did not identify specific causes.
  • Sensitivity analysis confirmed the stability of the results, and publication bias was not detected.

Conclusions:

  • COVID-19 patients with comorbid asthma in the UK may have a lower risk of mortality.
  • Routine intervention and treatment for asthma patients with severe acute respiratory syndrome coronavirus 2 infection should be maintained in the UK.

Keywords:
AsthmaCoronavirus disease 2019Meta-analysisMortalityUnited Kingdom

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