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Published on: January 23, 2018
Mechanistic insights into the beneficial effects of curcumin on insulin resistance: Opportunities and challenges
Pitchai Balakumar1, Kumar Venkatesan2, Noohu Abdulla Khan3
1The Office of Research and Development, Periyar Maniammai Institute of Science & Technology (Deemed to be University), Vallam, Thanjavur 613 403, Tamil Nadu, India.
Abstract:
The past couple of decades in particular have seen a rapid increase in the prevalence of type 2 diabetes mellitus (T2DM), a debilitating metabolic disorder characterised by insulin resistance. The insufficient efficacy of current management strategies for insulin resistance calls for additional therapeutic options. The preponderance of evidence suggests potential beneficial effects of curcumin on insulin resistance, while modern science provides a scientific basis for its potential applications against the disease. Curcumin combats insulin resistance by increasing the levels of circulating irisin and adiponectin, activating PPARγ, suppressing Notch1 signalling, and regulating SREBP target genes, among others. In this review, we bring together the diverse areas pertaining to our current understanding of the potential benefits of curcumin on insulin resistance, associated mechanistic insights, and new therapeutic possibilities.
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