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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
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Cellular drug delivery system for disease treatment
Luyue Wang1, Yu Zhang1, Yukun Ma2
1Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, PR China.
International Journal of Pharmaceutics
|May 24, 2023
Summary
Cell-based drug delivery systems (DDS) leverage unique cell functions for targeted drug delivery, offering prolonged circulation. This review explores various cell types used in DDS, promoting innovative development and clinical application.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Novel drug delivery systems (DDS) are increasingly important in medicine.
- Cell-based DDS represent a complex and intelligent approach to drug delivery.
- These systems utilize the inherent functions of cells for targeted therapeutic delivery.
Purpose of the Study:
- To review and analyze various types of cell-based drug delivery systems.
- To highlight recent research examples and advancements in cellular DDS.
- To provide a reference for future research and clinical translation of cell-based DDS.
Main Methods:
- Literature review of cell-based drug delivery systems.
- Analysis of common cellular components used in DDS (blood cells, immune cells, stem cells, tumor cells, bacteria).
- Examination of recent research examples and case studies.
Main Results:
- Cell-based DDS demonstrate potential for prolonged circulation compared to traditional DDS.
- Various cell types, including blood cells, immune cells, stem cells, tumor cells, and bacteria, are explored as drug carriers.
- Cellular DDS are identified as promising carriers for multifunctional drug delivery.
Conclusions:
- Cell-based DDS are an emerging and sophisticated frontier in drug delivery technology.
- Further research into cell vectors can drive innovation and clinical application of these systems.
- Cellular DDS hold significant promise for advancing targeted and effective therapies.
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Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
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01:16Drug Delivery: Overview
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01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
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01:22Drug Delivery: Miscellaneous Routes
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01:06Carrier-Mediated Transport
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01:29Drug Delivery: Parenteral Route
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