Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple hereditary trichoepitheliomas and basal cell carcinomas.

R J Pariser

    Journal of Cutaneous Pathology
    |April 1, 1986
    PubMed
    Summary

    Multiple hereditary trichoepitheliomas can exhibit malignant behavior, developing into basal cell carcinomas with follicular differentiation. This case highlights the potential for aggressive tumor progression in patients with this genetic condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Transport inhibitors released by 3t3 mouse cells and their relation to growth control.

    The Journal of cell biology·2009
    Same author

    A randomized trial of the efficacy of a new micronized formulation versus a standard formulation of isotretinoin in patients with severe recalcitrant nodular acne.

    Journal of the American Academy of Dermatology·2001
    Same author

    Safety of a new micronized formulation of isotretinoin in patients with severe recalcitrant nodular acne: A randomized trial comparing micronized isotretinoin with standard isotretinoin.

    Journal of the American Academy of Dermatology·2001
    Same author

    The relationship between biopsy technique and uncertainty in the histopathologic diagnosis of melanoma.

    Dermatology online journal·2000
    Same author

    A double-blind, placebo-controlled study of topical tetracaine in the treatment of herpes labialis.

    Journal of the American Academy of Dermatology·1999
    Same author

    Benign neoplasms of the skin.

    The Medical clinics of North America·1999

    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Multiple hereditary trichoepitheliomas (MHT) are rare benign skin tumors originating from follicular structures.
    • MHT is typically associated with mutations in the tumor suppressor gene CYLD.
    • While generally benign, the potential for malignant transformation in MHT is a critical area of investigation.

    Observation:

    • A 45-year-old male patient with a known diagnosis of MHT presented with two distinct tumors exhibiting aggressive characteristics.
    • Histopathological examination revealed these tumors possessed areas resembling undifferentiated basal cell carcinoma (BCC) alongside regions demonstrating significant follicular differentiation.
    • Additionally, the patient had multiple smaller, predominantly undifferentiated tumors interspersed among the trichoepitheliomas.

    Findings:

    • The observed tumors in this MHT patient demonstrated malignant behavior, specifically evolving into basal cell carcinomas.
    • These BCCs displayed a dual nature, with both undifferentiated and follicularly differentiated components.
    • The presence of interspersed smaller undifferentiated tumors further suggests a complex neoplastic process.

    Implications:

    • This case underscores the critical need for vigilant monitoring of patients with MHT due to the risk of malignant transformation.
    • Understanding the histopathological spectrum, including follicular differentiation within BCCs arising in MHT, is crucial for accurate diagnosis and treatment.
    • Further research into the molecular mechanisms driving malignant progression in MHT could lead to targeted therapeutic strategies.

    Related Experiment Videos