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Updated: Jul 29, 2025
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Published on: December 26, 2016
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Epigenetic regulons in Alzheimer's disease
Mahima Raval1, Sarita Mishra2, Anand Krishna Tiwari1
1Genetics & Developmental Biology Laboratory, Department of Biotechnology & Bioengineering, Institute of Advanced Research, Gandhinagar, Gujarat, India.
Summary
Epigenetics, heritable gene expression changes, are implicated in Alzheimer's disease (AD) development and progression. Understanding these epigenetic mechanisms may lead to new therapeutic strategies for AD.
Area of Science:
- Neuroscience
- Genetics
- Epigenetics
Background:
- Alzheimer's disease (AD) is a prevalent dementia in individuals over 65, characterized by amyloid plaques and neurofibrillary tangles.
- AD pathogenesis involves genetic and sporadic factors including age, lifestyle, oxidative stress, inflammation, insulin resistance, mitochondrial dysfunction, and epigenetics.
Purpose of the Study:
- To summarize the role of epigenetics in the onset and progression of Alzheimer's disease.
- To explore the potential of epigenetic therapeutics in ameliorating AD constraints.
Main Methods:
- Review of current literature on epigenetic mechanisms in Alzheimer's disease.
- Analysis of epigenetic alterations such as DNA methylation, hydroxymethylation, histone modifications, and non-coding RNA regulation in AD.
Main Results:
- Epigenetic mechanisms, including DNA methylation and histone modifications, are dysregulated in AD and play a key role in memory development.
- Alterations in AD-related genes at the transcriptional level contribute to disease pathogenesis.
- Epigenetic dysregulation impacts gene expression without altering DNA sequences, influencing AD development.
Conclusions:
- Epigenetics is a critical factor in the onset and progression of Alzheimer's disease.
- Epigenetic modifications are potential therapeutic targets for managing AD.
- Further research into epigenetic therapeutics could offer new avenues for AD treatment.
Keywords:
Alzheimer's diseaseChromatin remodelingDNA methylationEnvironmental factorsEpigeneticsHistone modificationsNeurodegenerative diseasesTherapeuticsMore Related Videos
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