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Related Concept Videos

Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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Related Experiment Video

Updated: Jul 29, 2025

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
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Epigenetics in renal diseases.

Sakshi1, Ragini1, Ashok Saini2

  • 1Department of Biotechnology, Regional Centre for Biotechnology, Faridabad, Haryana, India.

Progress in Molecular Biology and Translational Science
|May 24, 2023
PubMed
Summary
This summary is machine-generated.

Epigenetic modifications like DNA methylation and histone changes influence kidney disease progression. Understanding these mechanisms offers new avenues for diagnosis and treatment of renal diseases.

Keywords:
Acute kidney diseaseChronic kidney diseaseDNA methylationEpigeneticsHistone modificationNoncoding RNA

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Area of Science:

  • Nephrology
  • Epigenetics
  • Molecular Biology

Background:

  • Global increase in obesity, hypertension, diabetes, and renal diseases with aging.
  • Intensifying prevalence of renal diseases over the past two decades.
  • Epigenetic modifications, including DNA methylation and histone modifications, regulate renal disease and programming.

Purpose of the Study:

  • To explore the role of epigenetic mechanisms in renal diseases.
  • To understand the impact of environmental factors on renal disease pathophysiology.
  • To highlight the potential of epigenetic regulation for prognosis, diagnosis, and novel therapeutics.

Main Methods:

  • Review of epigenetic mechanisms: DNA methylation, histone modification, and noncoding RNA.
  • Analysis of their role in various renal diseases.
  • Focus on environmental factors influencing epigenetic regulation.

Main Results:

  • Epigenetic mechanisms are crucial in the pathophysiology of renal diseases.
  • Environmental factors significantly impact epigenetic regulation in the kidney.
  • Specific epigenetic alterations are linked to conditions like diabetic kidney disease and renal fibrosis.

Conclusions:

  • Epigenetic regulation plays a vital role in the development and progression of renal diseases.
  • Targeting epigenetic modifications presents promising therapeutic strategies for kidney diseases.
  • Further research into noncoding RNA and histone modifications is warranted for improved renal disease management.