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Genetic liability to multi-site chronic pain increases the risk of cardiovascular disease

Liling Lin1, Jianwei Lin2, Junxiong Qiu3

  • 1Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

British Journal of Anaesthesia
|May 24, 2023
PubMed

Insights

Multi-site chronic pain (MCP) causally increases the risk of cardiovascular diseases like heart failure and stroke. Mental disorders, smoking, physical activity, and BMI mediate this relationship, offering targets for intervention.

Area of Science:

  • Cardiovascular Medicine
  • Pain Medicine
  • Genetics

Background:

  • Observational studies suggest a link between multi-site chronic pain (MCP) and cardiovascular disease (CVD).
  • The causal nature of this association and potential mediating factors remain unclear.
  • This study investigates the causal relationship between MCP and CVD using genetic data.

Purpose of the Study:

  • To determine if multi-site chronic pain (MCP) causally influences the risk of cardiovascular disease (CVD).
  • To identify potential mediating factors, including lifestyle and biological markers, in the MCP-CVD relationship.

Main Methods:

  • A two-sample Mendelian randomization analysis was employed.
  • Genome-wide association study data for MCP (UK Biobank) and CVD subtypes were utilized.
  • Summary-level data for risk factors and biomarkers were analyzed to explore mediation.

Main Results:

  • Genetic liability to MCP significantly increased the risk of coronary artery disease, myocardial infarction, heart failure, and stroke.
  • MCP liability was associated with mental disorders, smoking initiation, physical activity, BMI, and lipid metabolites.
  • Multivariable Mendelian randomization indicated that mental disorders, smoking, physical activity, and BMI mediate the MCP-CVD link.

Conclusions:

  • Multi-site chronic pain (MCP) is a causal risk factor for cardiovascular disease (CVD).
  • Mental health, smoking, physical activity, and BMI are significant mediators in this relationship.
  • Targeting these modifiable risk factors may help reduce CVD risk in individuals with MCP.
Abstract

Keywords:
Mendelian randomisationcardiovascular diseasemediation analysismental disordersmulti-site chronic pain

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